Twelve weeks on a higher-quality diet led to significant improvements in measures of major depression in this small randomized controlled trial.

Dr. Georgia Ede reviews the 2017 SMILES trial, noting it supports “the common-sense notion that the human brain cares deeply about what we eat.” She concludes, “Clearly the most powerful way to fundamentally change your brain chemistry is through food, because that’s where the brain chemicals come from in the first place.”