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200514

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Inflammation and Oxidative Stress: The Molecular Connectivity Between Insulin Resistance, Obesity, and Alzheimer’s Disease

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A team of researchers from Curtin University in Australia conducted a literature review to identify the molecular commonalities of obesity, diabetes, and Alzheimer’s disease. Here, they examine the possible mechanisms behind the proposed connection.

Read MoreInflammation and Oxidative Stress: The Molecular Connectivity Between Insulin Resistance, Obesity, and Alzheimer’s Disease

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Jon Cohen
May 19th, 2020 at 4:58 pm
Commented on: Solution to the World's Greatest Problem

Not sure how Crossfit can talk about how refined carbs are the devil when the greatest crossfitter ever openly talks about adding Hershey’s Syrup to protein shakes for added carbs.

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Tyler Hass
May 19th, 2020 at 9:06 pm

Do you think Chocolate syrup is the secret to his success and CrossFit is dispensing bad advice? Or that he is not a true CrossFitter?

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Jon Cohen
May 23rd, 2020 at 6:51 pm

I suppose if I was forced to choose between those two without the benefit of nuance, the latter is closest to what I'm suggesting.

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Kathy Glassman
May 15th, 2020 at 11:15 pm
Commented on: Solution to the World's Greatest Problem

Yes!

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Matthieu Dubreucq
May 15th, 2020 at 3:23 pm
Commented on: Solution to the World's Greatest Problem

Covid 19 is only strengthening the necessity to take CrossFit seriously. Health is not a commodity, it is a series of actions that need to become habits. It all starts with recognizing that Health is a priority and then we need to go to the source and find the truth. Thanks CrossFit to help our community educate it self.


Il est important de comprendre que le Covid 19 ne fait que renforcer la nécessité de partager le message de CrossFIt. La santé n'est pas achetable, c'est une séries d'actions qui doivent devenir des habitudes. Premièrement faisant de notre santé notre priorité et puis il faut par la suite trouver la vérité sur la santé. Merci à CrossFit de nous aider à nous éduquer.

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Matteo Pozzati
May 15th, 2020 at 9:26 am
Commented on: Solution to the World's Greatest Problem

What a great message for our Community!


This is a tough subject to share among the people, especially here in Italy that has been bitten so hard by Covid 19, but at the same time the data are so evident that there's no way to do not agree whit this.


94% of the patients have a systemic inflammation due to preexisting conditions, like chronic illnesses. Those conditions are largely driven by lack of movement and by sugar and refined carbohydrates excessive consumption.


This means that if you want to stay away from this "High Risk Club" you need to do CrossFit, because the practical application of the "cure" is happening already thanks to all the CrossFit Affiliates around the world!


Thanks for this!!


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Che grande messaggio per la nostra comunità!


Questo è un argomento difficile da condividere tra le persone, specialmente qui in Italia che è stata colpita così duramente dal Covid 19, ma allo stesso tempo i dati sono così evidenti che non c'è modo di non essere d'accordo.


Il 94% dei pazienti ha un'infiammazione sistemica dovuta a condizioni preesistenti, come le malattie croniche. Tali condizioni sono largamente determinate dalla mancanza di movimento e dall'eccessivo consumo di zucchero e carboidrati raffinati.


Ciò significa che se vuoi stare lontano da questo "High Risk Club" devi fare CrossFit, perché l'applicazione pratica della "cura" sta già avvenendo grazie a tutti gli affiliati CrossFit in tutto il mondo!


Grazie!!

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Nicholas Acord
May 14th, 2020 at 11:13 pm
Commented on: Solution to the World's Greatest Problem

I'v been away from Crossfit for a few years, and I am very touched to see the different emphasis that I see on the site coming back. I appreciate videos like this: the diversity of people shown, and the focus on lifelong well-being. Not that Crossfit wasn't about that before--I just see that message becoming central.

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Pat Sherwood
May 14th, 2020 at 4:49 pm
Commented on: Solution to the World's Greatest Problem

100% spot on.

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Grant Shymske
May 14th, 2020 at 2:33 pm
Commented on: Inflammation and Oxidative Stress: The Molecular Connectivity Between Insulin Resistance, Obesity, and Alzheimer’s Disease

Isn't the slang term for Alzheimer's these days 'Type 3 Diabetes'. Seemingly for good reason.

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Aaron Webb
May 14th, 2020 at 8:42 pm

👍👍👍!!!

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Julia Perry
May 14th, 2020 at 1:40 pm
Commented on: Solution to the World's Greatest Problem

EXCELLENT! Thank you!

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John Sullivan
May 14th, 2020 at 1:15 pm
Commented on: Solution to the World's Greatest Problem

I've been telling my patient this forever. Sad to say but most are hoping for a vaccine. Frustrating at times but I don't give up.

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Tyler Hass
May 14th, 2020 at 11:32 pm

If you have chronic disease, waiting for the vaccine is playing Russian roulette. And no vaccine will reverse what made people vulnerable in the first place: metabolic syndrome.

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Tripp Starling
May 14th, 2020 at 1:09 pm
Commented on: Solution to the World's Greatest Problem

Wow. So good.

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Tom Cuff
May 14th, 2020 at 12:08 pm
Commented on: Solution to the World's Greatest Problem

This is my favorite piece of media I've seen you guys produce, really well done!

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Toni Anne Washington
May 14th, 2020 at 12:06 pm
Commented on: Solution to the World's Greatest Problem

This gave me chills and inspiration for our gym into the future... wellness and fitness for all!

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Grant Shymske
May 14th, 2020 at 10:43 am
Commented on: Solution to the World's Greatest Problem

Wake up call! Revolutionized fitness... Now revolutionizing health, let's keep going!

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Thomas Eichholzer
May 14th, 2020 at 9:49 am
Commented on: Inflammation and Oxidative Stress: The Molecular Connectivity Between Insulin Resistance, Obesity, and Alzheimer’s Disease

On the image, there is a term "Hypercholesterolaemia". I don't yet see the connection in the text. Usually we see that high cholesterol is not the problem. On the other hand high amounts of LDL seems do be a bad thing. And we have learned in earlier posts that messured LDL could potentially be Lp(a) instead. Can anyone enlighten me where is the connection in this text / respectively what produces LDL and Lp(a)? According to Wikipedia (on hypercholesterolaemia) its animal fats more than plant fats, but I don't think I should believe that.


By the way, I would like to hear more on gut bacteria. If there is a good point other than ethics in a vegan diet (in a well balanced vegan diet), than to me it is a better gut flora aka non-vegans should eat more veggies to better this (shouldn't a better gut flora reduce the production of Trimethylamine oxide even if one does not reduce meat intake?) etc.


Sorry, when I seem to be uninformed. But this one term in the image popped in my eyes, and I could not find it in the text.

(edited)
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Grant Shymske
May 14th, 2020 at 2:30 pm

I think you are the first person in an internet comment section not claiming to know and be right about everything. Kudos to you sir. I wish I could answer your initial question but I cannot. I agree with your desire to hear more about gut flora, my limited understanding and searching indicates that the science is still really new in that area and CrossFit seems to be trying hard to put out as concrete of information as possible so it may be a while. Purely anecdotal but my wife and I worked closely with the yoga community for many years (high proportion of Vegans) and I have never met a group of people with more nagging gut issues and little irritations and spells of temporary illness popping up here and there regularly, conversely, in the CrossFit gyms we've worked in the only instances of clients talking about gut issues have been vegetarians or clients still transitioning from the SAD diet. Grass fed steak and greens just seems to work, don't really need to know why (black box) just that it does.

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Gavin Heselton
May 14th, 2020 at 8:10 pm

I noticed that hypercholesterolaemia was listed in this process too. But I believe it is listed as an outcome of fat accumulation and weight gain rather than necessarily being causal of downstream effects.

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Dave Kritler
May 15th, 2020 at 12:17 am

Lp(a) is a subclass of LDL particle produced in the liver (that unfortunately is not assessed by the standard "lipid panel" that most doctors do which just determines total LDL ). Whether you have a lot of Lp(a) or not, is genetically determined. If you had one parent who had high Lp(a), you have a 50% chance of having it as well.


https://www.lipoproteinafoundation.org/ to learn more.


High Lp(a) is an independent risk factor for cardiovascular disease, whereas for most people high LDL is not (except for cases such as familial hypercholesteremia (FH)).


Because Lp(a) is poorly cleared by the body and circulates in the blood for a long time relative to plain old LDL, the cholesterol in it is more likely oxidized, thereby making it more atherogenic. My guess is that oxidative stress such as that described in this article might accelerate that process.


Look for work by Thomas Dayspring or Chris Masterjohn for all you ever wanted to know about lipids.

(edited)
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Thomas Eichholzer
May 15th, 2020 at 6:36 am

Thank you, guys. And thanks for the further resources, I will definitely give it a read.


I guess, and like being corrected, that LDL delivers fats to the cells. And HDL delivers fat back to the liver. So, more LDL means more fat storage and more HDL means using fat as energy (extremely simplified). Insulin controls those processes. So, a nonfunctional metabolism disturbs lipoproteins. (that’s the connection to the text I guess).


Black Box is great, but I’m still curious if one can do more to prevent atherosclerosis. How can someone reduce Lp(a)? How can someone reduce radicals? How can someone reduce trimethylamine oxide?

The movie “Game Changers” (which still leaves me angry for watching it) advocates cutting meat for exactly this. But I think of most people; they go to a Burger Chain and order a Burger, Fries with Coke. Cutting Meat means cutting the most and only healthy food from this plate. That’s where the movie goes wrong. But the movie got me more curious about atherosclerosis.


However, Crossfit style workouts and Crossfit style Nutrition seems to be THE SOLUTION. Guess I am looking for shortcuts.

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Emily Jenkins
May 14th, 2020 at 7:17 am
Commented on: Solution to the World's Greatest Problem

Love this! Thank you. Getting after it today via zoom.

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Candice Theron
May 14th, 2020 at 7:08 am
Commented on: Solution to the World's Greatest Problem

Excellent video! Showing the world how powerful doing CrossFit can be and how it save lives and reverses chronic disease.

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Reza Dehghanzadehsuraki
May 14th, 2020 at 4:45 am
Commented on: 200514

Macro view template analysis


Workout Structure:


First day was followed “AMRAP” template. This exercise was a couplet element that is combined of a moderate height jump from metabolic conditioning form with a moderate weightlifting movement. The training purpose is improving the lactic acid energy pathway and increases the lactate tolerance. Cardiorespiratory and muscular endurance played a major role in this WOD. Moreover, this exercise will involve lactic acid and aerobic energy pathways; however, the lactic acid system is the predominant system. Furthermore, short time for perform box jump will make use of phosphagen system.


Second day was followed both “For Completion” and “as many heavy as possible” template, respectively. Two formats of gymnastic and weightlifting were used in this high volume WOD. The purpose of the exercise was to perform the heaviest resistance in 3 repetitions. The reps selected so that challenge the strength. Strength, muscular endurance, flexibility, balance and coordination were challenged for GPP skills. Moreover, the aerobic system was a domain energy pathway for first part and the lactic acid system was a domain energy pathway for second part of this WOD. 


Third day was followed “For Time” template. This exercise was a couplet element that is combined of high distance metabolic conditioning and moderate skill gymnastic movements. Furthermore, this WOD is combined of 4 drills of running, pulling, pushing and squat movements manner. The main purpose in this WOD was on improving the cardiorespiratory endurance and stamina. The other purpose was to improving the lactate tolerance. Moreover, the aerobic

system was dominant energy pathway in this program.


Conclusion

As can be seen, each 3 energy pathways were challenged in this cycle. Moreover, the cardiorespiratory, muscular endurance, strength, stamina, flexibility,

balance and coordination played a major role in this circle of programming. Also, power is latent in the nature of these programs.

As a final note, “AMRAP”, “For Completion”, “AMHAP” and “For Time” templates were used for programming in this cycle.


Enjoy your rest day and recover your physical and mental dimensions

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Suzanne Johnson
May 14th, 2020 at 3:09 am
Commented on: Solution to the World's Greatest Problem

I totally agree that the method can solve this problem. However, the cost can be prohibitive! Belonging to a CrossFit gym costs more than many people can afford when they can barely afford food/shelter/clothing clothing. And a lot of the time, the people with less money in our society eat the worst because of food deserts/culture/lack of nutrition education. Maybe something like this can be subsidized by health insurance? I’m sure it would save billions in the long run.

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Mike Andridge
May 14th, 2020 at 3:55 am

Agree about the food issue, however crossfit.com is free and provides EVERYTHING a person needs. Nutrition-the food oasis is an issue; it provides food education, anatomy, training and many other resources.

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Chris Sinagoga
May 14th, 2020 at 7:21 pm

Like Mike said, they really do provide an offensive amount of stuff for free. Chris Meldrum and others have been doing this forever on their own without belonging to a gym (though, Mel will always be an honorary Champions Club kid!). But I do agree with you. The people who need it most as a whole have a difficult time getting in. I'm confident that will change over time though.

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Emiliano Rojas
May 14th, 2020 at 1:51 am
Commented on: Solution to the World's Greatest Problem

👌👏💪

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Chris Sinagoga
May 14th, 2020 at 1:20 am
Commented on: Solution to the World's Greatest Problem

Is this a video I can't embed or am I missing where the link usually is?


Great video, goes without saying.

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Andrew Hendel
May 14th, 2020 at 11:31 am
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Nathan Michael King
May 14th, 2020 at 12:37 am
Commented on: Solution to the World's Greatest Problem

Boom!

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