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190904

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21-15-9 reps for time of:

L pull-ups
Strict handstand push-ups

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Comments on A Different Perspective on the Treatment of Type 2 Diabetes

7 Comments

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Sven Braem
December 11th, 2019 at 8:02 pm
Commented on: A Different Perspective on the Treatment of Type 2 Diabetes

Generally OK with the concept of raised glucagon in T2D so I can understand the assumption that the same must be taking place under T1D since it produces very little to no insulin. However, that would miss the fact that T1D's do not continuously require insulin administration except in response to meals and other specific events that raise glucose. The following 2018 paper gives more insight into the morphology of alpha cells and why the situation is not a straightforward matter of hyperglucagonemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368357/

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RAPHAEL SIRTOLI
September 12th, 2019 at 1:06 pm
Commented on: A Different Perspective on the Treatment of Type 2 Diabetes

nice explanation of the bi-hormonal model diabetes, it's indeed more accurate than a hyperfocused message on blood sugars alone

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Richard Feinman
September 5th, 2019 at 9:37 pm
Commented on: A Different Perspective on the Treatment of Type 2 Diabetes

This is a great summary of the problem and excellent broad perspective. I think that insulin is still the master hormone or, more precisely, they are part of the same system. Glucagon stimulates a series of downhill processes and the ultimate conversion of glycogen to glucose is downhill energetically and must be regulated. The effect of insulin is negative and there are many such systems in biology. The retina, for example, is a dark receptor. I have a YouTube that describes some part of the problem: https://www.youtube.com/watch?v=STzB2USmKBg

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jr Wild
September 4th, 2019 at 6:03 am
Commented on: A Different Perspective on the Treatment of Type 2 Diabetes

An interesting and convincing concept, this lipotoxicity of the beta cells.

I tend to think of T2D as a longtime process, the final symptom of which is hyperglycemia. Sadly, the earlier symptoms do not routinely get tested (insulin with OGGT) or duely addressed (high TG / low HDL). The pancreatic fat graph of obese insulin resistant and T2D is almost equal, maybe the remaining difference is just hyperglycemia?


The late Dr. Kraft identified several patterns of insulin reaction abnormalities, which had two things in common: higher excretion and longer effect time, i.e. hyperinsulinemia that could still suppress hyperglycemia. Petro at Hyperlipid sliced and diced studies on ectopic fat, demonstrating the higher metabolic rate of those storages i.e. they are being 4 times more insulin sensitive than normal adipose tissues. Same with normalweight and obese, even though obese have slower fat oxidation capability. How about combining these two?


Ectopic storages are meant for short time use only? Ever increasing and prolonging insulin levels make surplus to this recurrent storage, and when fasting levels creep higher the storage become chronic due to high insulin sensitivity? I.e. waist circumference grows? At which stage the macrophages accumulate etc. Ectopic fat spillover to organs follows this or develops correspondingly, and lipotoxicity worsens gradually...


Insulin injection does not reach the pancreas with glucagon lowering effect? Treating just glucose number only is too little and partial, as indicated by Dr. Eades.


As the imbalances leading to T2D are many, it seems like a one-way street back to normality: reduce carbs (in order to reduce need for insulin letting glucagon "empty" the storages), the more the further “broken” your energy partitioning system is. Pre-diabetic does not necessarily need ketogenic i.e. therapeutic levels. Decreasing carbs works as a prevention/cure of metabolic syndrome, I would think (and have applied to myself).


Rgds JR

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Katina Thornton
September 4th, 2019 at 2:16 am
Commented on: A Different Perspective on the Treatment of Type 2 Diabetes

What I wish I understood is why most people aren't willing to make a lifestyle change instead of taking a pharmaceutical? What seems so clear to a few, isn't even a consideration for most.

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Andrea Bauer
September 4th, 2019 at 2:57 pm

Katina, we have long brainwashed by the medical field (and them by Big Pharma) that just taking medication will make it better. Also, the amount of nutrition education that doctors get is abysmal and most don't take the time to keep themselves up to speed with the proven dietary changes that can help their patients. Folks are still looking for that magic pill too. Why work for something when you can just take a pill or this case a shot. Sad state of affairs...

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VLADIMIR KALININ
September 6th, 2019 at 2:21 pm

I think the issue with lifestyle change is there is conflicting info and the methods frequently don't work as well as pharma's pills.

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