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Prevention of Heart Disease: Clinical Trials at What Cost?


In this 1975 review, Gina Kolata comments on the cost and necessity of two major clinical trial investments by the National Heart and Lung Institute (NHLI, now the NHLBI): the Lipid Research Clinics Primary Prevention Trial (LRC-PPT) and Multiple Risk Factor Intervention Trial (MRFIT). “With the passage of the Heart, Lung, and Blood Act in 1972, several large-scale clinical trials were planned to see whether people can voluntarily decrease their risk of heart disease. Now, 4 years later, screening for participants in the two most extensive and most expensive of these trials is nearly complete, but the trials are turning out to cost far more than anyone anticipated,” Kolata writes. As she notes, “A national obsession with dietary fats and cholesterol seems to have developed despite the fact that there is as yet no conclusive evidence that people can voluntarily decrease their risks of heart attacks by changing their diets.” Nevertheless, the LRC-PPT and MRFIT were seen as significant contributions to the diet-heart hypothesis and reflect the commitment on the part of research funders to find this missing evidence.

Read MorePrevention of Heart Disease: Clinical Trials at What Cost?

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Matthieu Dubreucq
December 29th, 2019 at 4:24 pm
Commented on: Prevention of Heart Disease: Clinical Trials at What Cost?

The obsession will take a long time to change in the "public knowledge" so it is important we keep educating as many people as possible.

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Max Guida
April 14th, 2019 at 10:03 pm
Commented on: 190414

12 min AMRAP:


Back squat 135 lbs


AbMat sit-ups

148 reps

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Stacey Carpenter
April 14th, 2019 at 7:55 pm
Commented on: 190414

ppp pullups program not feeling great in the tummy. A little cardio to get the juices going today.

Death by Going Prone: Start lying down and run 10m ever minute on the minute add one prone and one run until you can't complete all set moves in the minute.

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Nicole Deaver
April 14th, 2019 at 7:41 pm
Commented on: 190414

Rest Day!!

Active rest for me, 3 mile hike with the family.

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Kris Lopez-Kingston
April 14th, 2019 at 4:42 pm
Commented on: 190414

More like: Rest day....? Thank God!!!

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Evan Walton
April 14th, 2019 at 6:15 pm

I agree

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Julio Torres
April 14th, 2019 at 6:26 am
Commented on: 190414

Rest day....? No such thing!!!

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Katina Thornton
April 14th, 2019 at 3:25 am
Commented on: Prevention of Heart Disease: Clinical Trials at What Cost?

And this national pbsession with dietary fats and cholesterol has caused more morbidity and mortality than any other.

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