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Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance

ByCrossFit June 23, 2019

This 2004 article reviews the mechanisms by which exercise improves insulin sensitivity. Multiple streams of evidence suggest exercise has beneficial effects and sedentary behavior detrimental effects on insulin action and blood glucose control. The authors note that skeletal muscle insulin resistance is “the hallmark feature” of the obese and/or diabetic.

They discuss a variety of potential mechanisms by which inactivity could lead to skeletal muscle insulin resistance and activity could reverse it. Specifically:

  • Total muscular mitochondrial area is reduced in Type 2 diabetics, with a consequent reduction in muscular oxidative capacity; exercise increases muscular respiratory and oxidative capacity.
  • During exercise, insulin-stimulated glucose uptake is severely impaired in Type 2 diabetics compared to nondiabetics. A key mechanism by which insulin stimulates glucose uptake in muscle is through the translocation of GLUT4 transporters to the surface of the cell, where they pull glucose out of the blood. In the muscle cells of diabetics, levels of intracellular GLUT4 are normal, but insulin fails to stimulate their translocation to the outside of the cell — i.e., insulin’s signal is failing to reach the right proteins to stimulate glucose uptake. Exercise training has been shown to reverse these deficits and normalize the muscle’s ability to take in glucose when stimulated by insulin.
  • Exercise training increases the muscle’s ability to oxidize fat, which is impaired (for reasons directly related to the mitochondrial deficits noted above) in diabetics.

In other words, skeletal muscle insulin resistance — and thus, to a large extent, overall insulin resistance — in diabetic subjects is due to reduced mitochondria production and/or activity and reduced insulin signaling in muscle cells. Exercise has been shown to reverse these deficits.

As the authors conclude:

Given the strong evidence for a direct role of physical activity in the prevention of insulin resistance, and the fact that exercise training increases mitochondrial biogenesis and improves glucose tolerance and insulin action in individuals with insulin resistance and type 2 diabetes, the question of why such a potent modulator of these conditions is not more commonly prescribed is perplexing and should be of utmost concern to medical health care professionals worldwide. To continue to attack the growing health burden by investing almost exclusively in strategies that target secondary and tertiary treatment of chronic disease states (i.e. pharmaceutical interventions) is extremely short sighted: primary defence mechanisms (i.e. exercise/diet and lifestyle interventions) will decrease disease prevalence by preventing these conditions in the first place!

Figure 1 below summarizes these mechanisms.

Figure 1

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