Comments on Insulin Resistance and Hyperglycaemia in Cardiovascular Disease Development
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Pat Sherwood
March 26th, 2020 at 3:56 pm
Commented on: Insulin Resistance and Hyperglycaemia in Cardiovascular Disease Development
It is amazing how many things come back to some very simple steps...eat the proper foods in the proper amounts.
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Joe Westerlin
March 26th, 2020 at 1:10 pm
Commented on: Insulin Resistance and Hyperglycaemia in Cardiovascular Disease Development
Ah, the ‘freshman 15’, it’s the seemingly harmless ‘party fun’ that accumulates around the mid-section for 20 million college students. Harmless is the keyword here, or at least in the eyes of the afflicted, as is the oft undetected (or ignored) slight increase in blood pressure, glucose, and triglycerides. These small changes in the body have been shrugged off for generations as just “part of getting older”, when in reality this is the beginning of the pathology that writes the great story of our time...heart disease (and much more). And it all began with insulin.
Many now understand the toxicity of glucose, but many however do not know about the toxicity of insulin itself. The dangers of insulin resistance <> hyperinsulinemia are the equal risk they pose to those with normal glucose tolerance, impaired glucose tolerance, and diabetic glucose tolerance. Having normal glucose tolerance (“not diabetic”) seems to offer little more protection than diabetic glucose tolerance from pathology: endothelial dysfunction > to wide spread vascular pathology > to the inevitable angiopathy (in the smallest to the largest vessels.)
The scariest part to me is that what used to be the freshman (in college) 15, turned into the junior (in high school) 15, and now seems to be on its way to the 5th grade 15.
https://www.youtube.com/watch?v=VrLWPuXbvLM
(edited)
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Nathan Jenkins
March 26th, 2020 at 4:21 am
Commented on: Insulin Resistance and Hyperglycaemia in Cardiovascular Disease Development
Fortunately, muscle contraction is a powerful signal to stimulate glucose uptake, completely independent of the insulin mechanism. This means that patients with T1D and T2D have an alternative mechanism for glycemic regulation even with a faulty insulin-mediated glucose disposal system, whether that's due to a lack of insulin production (T1D), insulin resistance (impaired glucose tolerance/early T2D), or both (advanced T2D). And the effects are rapid; studies show that even a single exercise session can confer glycemic benefit. Seems like the greater the muscle mass involved, and the higher the power output (intensity), the better. Hmm.
Great review article! Very solid evidence for CrossFit's longstanding position on hyperglycemia and insulin resistance as the major pathologic mechanism underlying chronic disease. Mainstream medical science divides and partitions the pathologies into distinct categories: muscle insulin resistance is one, and then there's also pancreatic beta cell dysfunction, excess hepatic glucose output, adipose inflammation, kidney disease, endothelial dysfunction, hypertension, erectile dysfunction, coronary heart disease, etc. There is an argument to be made that these are all symptoms of one underlying, unifying condition: insulin resistance, acquired through poor lifestyle habits, i.e. excess food intake (primarily sugar consumption), worsened by lack of exercise.
Comments on Insulin Resistance and Hyperglycaemia in Cardiovascular Disease Development
3 Comments