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In this 2012 review, Jack W. Scannell, Alex Blanckley, Helen Boldon, and Brian Warrington discuss “Eroom’s Law,” which focuses on the drug market instead of technology and is the opposite of Moore’s Law in name and concept: The cost of developing a new drug doubles approximately every nine years, indicating that the number of drugs approved per billion dollars spent has fallen 80-fold since 1950. The authors review four major factors for this phenomenon.

A growing body of evidence suggests added sugars play a role in the development and/or progression of fatty liver disease. A 2018 trial, led by Miriam Vos (Emory) and Jeffrey Schwimmer (UCSD), considered whether removing added sugar from the diet could improve fatty liver disease in children. The authors conclude, “In this study of adolescent boys with NAFLD, 8 weeks of provision of a diet low in free sugar content compared with usual diet resulted in significant improvement in hepatic steatosis.”

"Overweight children with fatty liver disease sharply reduced the amount of fat and inflammation in their livers by cutting soft drinks, fruit juices and foods with added sugars from their diets, a rigorous new study found. The new research, published in JAMA, suggests that limiting sugary foods and drinks may be a promising lifestyle strategy to help alleviate a devastating condition linked to the obesity crisis that is spreading rapidly in adults and children. An estimated 80 million to 100 million Americans have nonalcoholic fatty liver disease, which causes the liver to swell with dangerous levels of fat. Roughly seven million of those are adolescents and teenagers."

This brief 2013 review summarizes two studies investigating the metabolic impact of fructose overconsumption, placing them in the broader context of the scientific literature. The authors note that “diets high in fructose could cause excess fat accumulation in the liver, leading to ... fatty liver disease, steatohepatitis and, ultimately, cirrhosis. Liver fat could also be released into the circulation and taken up by fat cells in other tissues, resulting in obesity. Furthermore, the circulating fat could accelerate the onset of cardiovascular disease, insulin resistance and type 2 diabetes. So fructose over-consumption may be at the heart of metabolic syndrome, which has also been linked to poor outcome of a wide range of cancers.”